Protein adsorption on nano-scaled, rippled TiO₂ and Si surfaces

verfasst von

Jana Sommerfeld, Jessica Richter, Raphael Niepelt, Stefanie Kosan, Thomas F. Keller, Klaus D. Jandt, Carsten Ronning

Abstract

We synthesized nano-scaled periodic ripple patterns on silicon and titanium dioxide (TiO₂) surfaces by xenon ion irradiation, and performed adsorption experiments with human plasma fibrinogen (HPF) on such surfaces as a function of the ripple wavelength. Atomic force microscopy showed the adsorption of HPF in mostly globular conformation on crystalline and amorphous flat Si surfaces as well as on nano-structured Si with long ripple wavelengths. For short ripple wavelengths the proteins seem to adsorb in a stretched formation and align across or along the ripples. In contrast to that, the proteins adsorb in a globular assembly on flat and long-wavelength rippled TiO₂, but no adsorbed proteins could be observed on TiO₂ with short ripple wavelengths due to a decrease of the adsorption energy caused by surface curvature. Consequently, the adsorption behavior of HPF can be tuned on biomedically interesting materials by introducing a nanosized morphology while not modifying the stoichiometry/ chemistry.

Externe Organisation(en)

Friedrich-Schiller-Universität Jena

Typ

Artikel

Journal

BIOINTERPHASES

Band

7

Seiten

1-7

Anzahl der Seiten

7

ISSN

1934-8630

Publikationsdatum

2012

Publikationsstatus

Veröffentlicht

Peer-reviewed

Ja

ASJC Scopus Sachgebiete

Allgemeine Chemie, Biomaterialien, Allgemeine Materialwissenschaften, Allgemeine Biochemie, Genetik und Molekularbiologie, Allgemeine Physik und Astronomie

Elektronische Version(en)

https://doi.org/10.1007/s13758-012-0055-5 (Zugang: Geschlossen)